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          EU Amends REACH Regulation, Adds 16 New CMR Substances

          from CIRS by

          On August 11, 2025, the European Commission formally adopted Commission Regulation (EU) 2025/1731, amending Annex XVII of the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) Regulation to strengthen controls over Carcinogenic, Mutagenic, or Reproductive Toxic (CMR) substances.

          Key Amendments

          The following 16 CMR substances have been added to REACH Annex XVII:

          Substances

          EC No

          CAS No

          Hazard Classification

          ‘diuron (ISO); 3-(3,4-dichlorophenyl)-1,1-dimethylurea

          206-354-4

          330-54-1

          Carcinogen Category 1B

          ‘2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol; tetrabromobisphenol-A

          201-236-9

          79-94-7

          Carcinogen Category 1B

          ‘N,N-dimethyl-p-toluidine

          202-805-4

          99-97-8

          Carcinogen Category 1B

          ‘4-nitrosomorpholine

          -

          59-89-2

          Carcinogen Category 1B

          ‘4-methylimidazole

          212-497-3

          822-36-6

          Carcinogen Category 1B, Reproductive Toxicity Category 1B

          ‘dimethyl propylphosphonate

          242-555-3

          18755-43-6

          Mutagen Category 1B, Reproductive Toxicity Category 1B

          ‘diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

          278-355-8

          75980-60-8

          Reproductive Toxicity Category 1B

          ‘benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate

          479-100-5

          577705-90-9

          Reproductive Toxicity Category 1B

          ‘benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[phenol] (1:1)

          278-305-5

          75768-65-9

          Reproductive Toxicity Category 1B

          ‘reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate (1:1)

          -

          -

          Reproductive Toxicity Category 1B

          ‘reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol (1:1)

          -

          -

          Reproductive Toxicity Category 1B

          ‘dibutyltin maleate

          201-077-5

          78-04-6

          Reproductive Toxicity Category 1B

          ‘dibutyltin oxide

          212-449-1

          818-08-6

          Reproductive Toxicity Category 1B

          ‘reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane

          -

          -

          Reproductive Toxicity Category 1B

          ‘4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF

          216-036-7

          1478-61-1

          Reproductive Toxicity Category 1B

          ‘1,4-Benzenediamine, N,N’-mixed Ph and tolyl derivs.;

          273-227-8

          68953-84-4

          Reproductive Toxicity Category 1B

          Derogations

          Substances

          CAS No

           

          EC No

          Derogations

          Cumene

           98-82-8

          202-704-5

          As a substance on its own or as a constituent of other substances in either of the following:

          (a)   kerosene used as aviation fuel conforming to DEF STAN 91-091, ASTM specification D1655 or equivalent recognised standards and marketed under descriptions such as Jet-A, Jet-A1 or JP-(x);

          (b) gasoline used as aviation fuel conforming to DEF STAN 91-090, ASTM D910, ASTM D7547 or equivalent recognised standards.

          Regulatory Timeline

          Restrictions on the new Category 1B CMR substances will officially take effect on September 1, 2025, and apply directly across all EU member states.

          If you need any assistance or have any questions, please get in touch with us via service@cirs-group.com.

          Further Information

          Official Journal

           

            

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