EU Drafts Update to REACH Annex XVII to Further Regulate CMR Substances

On January 9, 2026, the European Commission released a draft proposal to technically update Annex XVII of the REACH Regulation. This aims to align with the new hazard classifications added under the CLP Regulation in 2024 and 2025. The core amendments involve expanding the list of restricted Carcinogenic, Mutagenic or Toxic for Reproduction (CMR) substances.

Key Updates

Appendix 1 (Carcinogens: Category 1A)

New Substance	EC No	CAS No
Vinyl fluoride	200-832-6	75-02-5

Appendix 2 (Carcinogens: Category 1B)

New Substance	EC No	CAS No
Multi-walled carbon tubes (synthetic graphite in tubular shape) with a geometric tube diameter range ≥ 30 nm to < 3 μm and a length ≥ 5 μm and aspect ratio > 3:1, including multi-walled carbon nanotubes, MWC(N)T	–	–
Acetone oxime	204-820-1	127-06-0
Benthiavalicarb-isopropyl (ISO); isopropyl [(S)-1-{[(R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]carbamoyl}-2-methylpropyl]carbamate	–	177406-68-7
1,4-Dichloro-2-nitrobenzene	201-923-3	89-61-2
Trimethyl phosphate	208-144-8	512-56-1
Barium chromate	233-660-5	10294-40-3
1,1-dichloroethylene; vinylidene chloride	200-864-0	75-35-4

Appendix 4 (Germ cell mutagens: Category 1B)

New Substance	EC No	CAS No
N,N′-Methylenediacrylamide	203-750-9	110-26-9
Trimethyl phosphate	208-144-8	512-56-1

Appendix 6 (Reproductive toxicants: Category 1B)

New Substance	EC No	CAS No
Trimethyl borate	204-468-9	121-43-7
Perboric acid, sodium salt [1] Perboric acid, sodium salt, monohydrate [2] Perboric acid (HBO(O?)), sodium salt, monohydrate [3] Sodium peroxoborate [4] Sodium perborate [5]	234-390-0 [1] 234-390-0 [2] - [3] -[4] 239-172-9 [5]	11138-47-9 [1] 12040-72-1 [2] 10332-33-9 [3] - [4] 15120-21-5 [5]
Perboric acid (H?BO?(O?)), monosodium salt trihydrate [1] Perboric acid, sodium salt, tetrahydrate [2] Perboric acid (HBO(O?)), sodium salt, tetrahydrate [3] Sodium peroxoborate, hexahydrate [4]	239-172-9 [1] 234-390-0 [2] - [3] - [4]	13517-20-9 [1] 37244-98-7 [2] 10486-00-7 [3] - [4]
Sodium peroxometaborate	231-556-4	7632-04-4
Reaction mass of 1,3-dioxan-5-ol and 1,3-dioxolan-4-ylmethanol	–	–
2-(Dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one	438-340-0	119344-86-4
Sodium 3-(allyloxy)-2-hydroxypropanesulphonate	258-004-5	52556-42-0
Tert-butyl 2-ethylperoxyhexanoate	221-110-7	3006-82-4
Dinitrogen oxide (N?O)	233-032-0	10024-97-2
Trimethyl phosphate	208-144-8	512-56-1
2-Bromo-3,3,3-trifluoroprop-1-ene	–	1514-82-5
2,3-Epoxypropyl isopropyl ether	223-672-9	4016-14-2
α,α'-Propylenedinitrilodi-o-cresol	202-374-2	94-91-7
2-Ethylhexanoic acid, monoester with propane-1,2-diol	285-503-5	85114-00-7
Tetrahydrofurfuryl methacrylate	219-529-5	2455-24-5
9-Octadecenoic acid (Z)-, sulfonated, potassium salts [1] Reaction products of fatty acids, C18 (unsaturated) alkyl with sulfur trioxide, potassium salts [2] 9(Or 10)-sulphooctadecanoic acid, potassium salt [3]	271-843-1 [1] - [2] 267-966-5 [3]	68609-93-8 [1] - [2] 67968-63-2 [3]

This draft is currently open for public consultation. The deadline for submitting comments is February 6, 2026. Once adopted, the regulation will enter into force 20 days after its publication in the Official Journal of the European Union.

If you need any assistance or have any questions, please get in touch with us via service@cirs-group.com.

Further Information

European Commision

We have launched a LinkedIn newsletter to keep you up to date on the latest developments across the chemical industry including food and FCMs and personal and home care.