44 Substances Added into China’s Inventory of Existing Chemical Substances

On May 6, 2025, the Ministry of Ecology and Environment of China (MEE) added 44 substances to the Inventory of Existing Chemical Substances in China (IECSC), and revised the permitted uses of two substances.

CIRS warmly reminds related enterprises that they must know whether their substances are new or existing substances. The Provisions on Environmental Administration of New Chemical Substances (MEE Order 12) requires enterprises to complete new substance registration/record before manufacturing or importing, or they may face various punishments.

To find out whether a substance is listed in IECSC, please search our free tool – ChemRadar.

The MEE issued Announcement No. 9 of 2025, declaring updates to the IECSC.

Industry Alert: Due Diligence Required Before Registration

Before registering new chemical substances, companies should verify whether the substance is new. If the substance is not listed in the IECSC, it is necessary to engage a professional agency to perform a confidential search to determine if it qualifies as a new chemical substance, thus avoiding wasting resources.

Two Typical Cases:

Case 1: A company failed to conduct a search and erroneously declared a substance, already listed in the confidential section of the inventory, as a new substance, leading to wasted costs in testing, time, and human resources.

Case 2: Another company was able to halt its declaration process in time due to dynamic updates to the inventory, thereby reducing losses.

Conducting a search not only avoids futile declarations but also provides a basis for companies to address subsequent disputes. As the frequency of updates to the inventory increases, companies must stay alert and combine professional services to optimize compliance strategies.

This update is a crucial step by the MEE to strengthen the full lifecycle management of chemical substances, aiming to balance industry innovation with ecological safety. In the future, the dynamic adjustment mechanism of the inventory will be further refined to support the environmental risk prevention and control goals for chemical substances during the 14th Five-Year Plan period.

Details

Annex 1

Additions to the Inventory of Existing Chemical Substances in China

SN	Name	Alias	Molecular Formula	CAS No. or Serial Code
1	Butanoic acid, 2-hydroxy-4-(methylthio)-		C5H10O3S	583-91-5
2	Diisopropyl xanthogen disulfide	Accelerator DIP	C8H14O2S4	105-65-7
3	Benzoic acid, 4-nitro-, ammonium salt (1:1)	Ammonium p-nitrobenzoate	C7H5NO4.H3N	19416-70-7
4	Dodecanedioic acid, ammonium salt (1:?)		C12H22O4.xH3N	59864-79-8
5	Triammonium citrate		C6H17N3O7	3458-72-8
6	1-(Chloromethyl)-4-fluorobenzene	p-Fluorobenzyl chloride; 4-Fluorobenzyl chloride; Benzene,1-(chloromethyl)-4-fluoro-	C7H6ClF	352-11-4
7	4-Thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)-	Tazobactam	C10H12N4O5S	89786-04-9

Annex 2

Registered chemical substances added to the Inventory of Existing Chemical Substances in China

SN	Class Name	Serial Code	Scope of New Usage Management
1	Halogeno-dihydro-oxoindenecarboxylic acid alkyl ester	9911	Industrial uses other than those permitted for use. Permitted uses: Pesticide intermediate
2	Aluminoxanes, alkyl, alkyl group-terminated, reaction products with silica, halogenated, reaction products with bis(alkyl-alkylcyclopentadienyl]dihalogeno (transition metal)	9912
3	[Amino-(alkylamino)benzoyl]-(azaaryl) alanine alkyl ester	9913
4	1H-Pyrazole-carbonyl fluoride, substituted	9914	Industrial uses other than those permitted for use. Permitted uses: Pesticide intermediate
5	Halogenosulfonic acid alkali metal salt	9915
6	Formaldehyde, telomer with aromaticamine, benzenediol and aromaticalkene	9916	Industrial uses other than those permitted for use. Permitted uses: Curing agent for adhesive mortar used in construction work
7	Amides, tallow, N,N-bis(substituted alkyl)	9917	Industrial uses other than those permitted for use Permitted uses: Lubricant additives
8	Alkyloxy(aliphatic polyol)	9918

SN	Class Name	Serial Code	Scope of New Usage Management
9	Reaction products of disubstituted arene and alkanol	9919
10	Bis(halogenoaryl)-dioxo-dihydropyrrolopyrrole, sulfo derivs.	9920	Industrial uses other than those permitted for use Permitted uses: LCD colour filter photoresist material
11	Alkyloxyphenyl-nitrophenyl-oxoheteropolycyclic-carboxylic acid, ethyl ester	9921
12	Metal silicate	9922
13	Polyalkylalkoxycyclohexane	9923	Industrial uses other than those permitted for use. Permitted uses: Fragrance ingredients in oral care products
14	Hydroxy-oxoheteroaromatic metallic compounds	9924	Industrial uses other than those permitted for use. Permitted uses: Paint catalyst
15	2H-Indazole-7-carboxamide, heteromonocyclic phenyl-, alkylcarbomonocyclic sulfonate, hydrate	9925	Industrial uses other than those permitted for use. Permitted uses: Pharmaceutical intermediates
16	Reactive red azo dyes	9926
17	Sulfo(aliphatic polycarboxylic acid)[(polyhalogenoalkoxy)-(alkyl)alkyl] esters, sodium salt	9927
18	Alkenoic acid, aryl ester	9928
19	Reactionproductsof diazotised benzenesulfonic acid, substituted[[(sulfooxy)alkyl]sulfonyl]-, subsequently coupled with benzoic acid, multiamino-, further coupled with diazotised alkanol,[(aminoaryl)sulfonyl]-, (hydrogen sulfate), metal salts	9929
20	Bis(cycloalkylalkyl) ether	9930	Industrial uses other than those permitted for use. Permitted uses: flavoring materials

SN	Class Name	Serial Code	Scope of New Usage Management
21	Lithium ((tert-butoxycarbonyl)piperidin-3-yl)aryl-2H-heteropolycyclic-7-carboxylate	9931
22	N-[4-[[2-Amino-multihydro-4-substituted-6- pteridinyl)alkyl]amino] alkyl]-L-glutamic acid	9932
23	Polyhalogenated phosphorous acid, alkyl ester	9933
24	Oxa(polycyclic arene), bis(hydroxyaryl)-oxo-, reaction products with aniline and epichlorohydrin	9934
25	4-[[(Halodialkylphenyl)alkanoyl]alkylamino]-alkoxy-N-phenylpiperidinecarbox amide	9935	Industrial uses other than those permitted for use. Permitted uses: Pesticide intermediate
26	Ethyl alkyl-substitutedcycloalkanecarboxylate	9936
27	Methyl(alkylcyclohexyl)biphenyl	9937
28	3-[(2R)-2-amino-2-arylalkyl]-5-(2-halo-3-alkoxyphenyl)-1-{[2-halo-6-substituted phenyl]alkyl}-6-alkypyrimidine-2,4(1H,3H)-dione 2-hydroxyarylcarboxylate (1:1)	9938	Industrial uses other than those permitted for use. Permitted uses: Pharmaceutical intermediates
29	N-Substituted-L-prolinamide	9939
30	(Amino-thiadiazolyl)-[alkyl-[(alkyl)oxy]-oxopropanyl]oxyiminoacetic acid	9940
31	Alkyl (((alkyl-polyarylmethylamino-1H-pyrazolyl) ureido)alkyl)carbamate	9941

SN	Name	Molecular Formula	CAS No. or Serial Code	Scope of New Usage Management
32	Methyl (2E)-2-(2-chloromethylphenyl)-3-methoxy-2-acrylate	C12H13ClO3	117428-51-0	Industrial uses other than those permitted for use. Permitted uses: Pesticide intermediate
33	Thiirane, 2,2'-[thiobis(methylene)]bis-	C6H10S3	188829-97-2
34.	1,3,2-Dioxathiolane, 2,2-dioxide	C2H4O4S	1072-53-3
35	1H-Imidazole-1-propanenitrile, 2-ethyl-ar-methyl-	C9H13N3	568591-00-4
36	Alkenes, C10-16 α-, reaction products with (6E)-7, 11-dimethyl-3-methylene-1,6,10-dodecatriene,hydrogenated	(CnH2n • C15H24) • H2 n=10~16	1481694-12-5
37	Fatty acids,C12-14,reaction products with sulfur trioxide, sodium salts	Undecided	2215087-54-8

Annex 3

Existing Substances with Changes to the Permitted Uses

Class Name

Serial Code

Scope of New Usage Management

Imidazolium, dialkyl-, branched alkylbenzenesulfonates

9645

Industrial uses other than those permitted for use.

Permitted uses: Antistatic agent for resins

Dialkyl phosphate metal salt

9608

Industrial uses other than those permitted for use.

Permitted uses: Automotive engine oil lubricant additives, gas engine oil lubricant additives

Note: According to Annexes 1 and 2, a total of 44 chemical substances have been incorporated into the IECSC. The MEE emphasizes that by the end of 2025, all chemicals that have completed their regular notifications under the former MEP Order No. 7 will be included in the IECSC.

If you need any assistance or have any questions, please get in touch with us via service@cirs-group.com.

Further Information

MEE Notice in Chinese

The Inventory of Existing Chemical Substances in China – IECSC (2013 and updates)

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