國家藥監局組織起草的《牛角膜渾濁度和滲透性試驗方法》《體外皮膚變態反應 動力學直接多肽反應試驗方法》《皮膚吸收體外試驗方法》《免疫毒性試驗方法》《口腔黏膜刺激試驗方法》等5項方法，經國家藥監局化妝品標準化技術委員會主任會議審查通過，現予以發布，納入《化妝品安全技術規范（2015年版）》相應章節（見附件）。
上述5項方法均為新增方法，自2026年3月1日起實施。在實施前，鼓勵化妝品注冊、備案相關檢驗采用上述方法。
特此通告。
附件：1.《化妝品安全技術規范（2015年版）》5項標準制定項目匯總表
2.牛角膜渾濁度和滲透性試驗方法
3.體外皮膚變態反應 動力學直接多肽反應試驗方法
4.皮膚吸收體外試驗方法
5.免疫毒性試驗方法
6.口腔黏膜刺激試驗方法
國家藥監局
2025年8月28日
附件1.《化妝品安全技術規范（2015年版）》5項標準制定項目匯總表.doc
附件2.牛角膜渾濁度和滲透性試驗方法.docx
附件3 體外皮膚變態反應 動力學直接多肽反應試驗方法.docx.docx
附件4 皮膚吸收體外試驗方法.docx
附件5 免疫毒性試驗方法.docx
附件6 口腔黏膜刺激試驗方法.docx
掃描下方的二維碼訂閱“妝合規”！跟蹤化妝品最新產品安全與法規監管動態, 深入洞察化妝品研發與上市信息, 集萃行業大咖獨家觀點，獲得最新一手資訊。
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